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Microcephaly - Wikipedia
Microcephaly (from New Latin microcephalia, from Ancient Greek μικρός mikrós "small" and κεφαλή kephalé "head") is a medical condition involving a smaller-than-normal head. Microcephaly may be present at birth or it may develop in the first few years of life. Since brain growth is correlated with head growth, people with this disorder often have an intellectual disability, poor ...

Facts about Microcephaly | CDC
Microcephaly can be diagnosed during pregnancy or after the baby is born. During Pregnancy. During pregnancy, microcephaly can sometimes be diagnosed with an ultrasound test (which creates pictures of the body). To see microcephaly during pregnancy, the ultrasound test should be done late in the 2nd trimester or early in the third trimester.

Microcephaly - Symptoms and causes - Mayo Clinic
Microcephaly usually is the result of a problem with brain development, which can occur in the womb (congenital) or during infancy. Microcephaly may be genetic. Other causes may include: Craniosynostosis (kray-nee-o-sin-os-TOE-sis).

Microcephaly: Causes, Diagnosis, Treatment & Outcome
Microcephaly occurs most often because the brain fails to grow at a normal rate. This can be caused by a variety of conditions or by exposure to harmful substances while the baby is in the womb. Some of these causes include: Genetic (inherited) disorders such as Down syndrome;

Microcephaly - PMC
Microcephaly is defined as a head circumference more than two standard deviations below the mean for gender and age. Congenital microcephaly is present at birth, whereas postnatal microcephaly occurs later in life. Genetic abnormalities, syndromes, metabolic disorders, teratogens, infections, prenatal, perinatal, and postnatal injuries can ...

For Pregnant Women | Zika virus | CDC
Zika virus can be passed from a pregnant woman to her fetus. Infection during pregnancy can cause a birth defect called microcephaly and other severe fetal brain defects; Zika primarily spreads through infected mosquitoes.You can also get Zika through sex without a condom with someone infected by Zika, even if that person does not show symptoms of Zika.

Cerebral organoids model human brain development and microcephaly
Finally, we use RNA interference and patient-specific induced pluripotent stem cells to model microcephaly, a disorder that has been difficult to recapitulate in mice. We demonstrate premature neuronal differentiation in patient organoids, a defect that could help to explain the disease phenotype. Together, these data show that three ...

Microcephaly - Diagnosis and treatment - Mayo Clinic
To determine if your child has microcephaly, your provider likely will take a thorough prenatal, birth and family history and do a physical exam. Your provider will measure the circumference of your child's head, compare it with a growth chart, and remeasure and plot the growth at future visits. Parents' head sizes also may be measured to ...

Zika virus disease - WHO
Zika virus is primarily transmitted by the bite of an infected mosquito from the Aedes genus, mainly Aedes aegypti, in tropical and subtropical regions. Aedes mosquitoes usually bite during the day, peaking during early morning and late afternoon/evening. This is the same mosquito that transmits dengue, chikungunya and yellow fever.

Aberrant NAD + metabolism underlies Zika virus-induced microcephaly
Zika virus (ZIKV) infection during pregnancy can cause microcephaly in newborns, yet the underlying mechanisms remain largely unexplored. Here, we reveal extensive and large-scale metabolic reprogramming events in ZIKV-infected mouse brains by performing a multi-omics study comprising transcriptomics, proteomics, phosphoproteomics and metabolomics approaches.

 

 

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